Fasciola hepatica
نویسندگان
چکیده
18 The success of helminth parasites is partly related to their ability to modulate host immune 19 responses towards an anti-inflammatory/regulatory phenotype. This ability resides with the 20 molecules contained in the secretome of various helminths that have been shown to interact with 21 host immune cells and influence their function. Consequently, there exists a unique opportunity 22 to exploit these molecules for the prophylactic and therapeutic treatment of human proand auto23 inflammatory disorders (for example septic shock, transplant rejection and autoimmune disease). 24 In this review, we describe the mechanisms used by the trematode parasite, Fasciola hepatica, to 25 modulate the immune responses of its host and discuss the potent immune-modulatory effects of 26 three individual molecules within the secretome; namely cathepsin L1, peroxiredoxin and 27 helminth defence molecule. With a focus on the requirements from industry, we discuss the 28 strategies by which these molecules may be clinically developed to control human immune 29 responses in a way that is conducive to the prevention of immune-mediated diseases. 30 31
منابع مشابه
Determination of somatic and excretory-secretory antigens of Fasciola hepatica and Fasciola gigantica using SDS-PAGE
Human fascioliasis due to unknown species and animal fascioliasis caused by both or one of Fasciola spp. are commonly seen in Iran. To compare electrophoretic patterns of somatic and excretory-secretory antigens of F. hepatica and F. gigantica by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE), the adult flukes were collected from infected slaughtered bovine livers. E/S a...
متن کاملFurther Observation on the Susceptibility of Different Species of Lymnaea Snails of Iran to Miracidia of Fasciola hepatica and Fasciola gigantica
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The prevalence of Fasciola hepatica L. infection in cattle in the Lublin province in the years 2009-2012.
Prevalence of Fasciola hepatica L. infection among cattle slaughtered in the Lublin province in from 2009-2012 was evaluated. The data were taken from annual reports of the Veterinary Inspectorate in Lublin. The results of the study are as follows: the prevalence of Fasciola hepatica infection in the cattle of the Lublin province between 2009 and 2012 is found to be 11.97%.
متن کاملPartial Hepatectomy for the Resistant Fasciola Hepatica Infection in a Child
Fascioliasis is an emerging and important chronic parasitic disease caused by two trematode liver fluke species: Fasciola hepatica (F. hepatica) and Fasciola gigantica (F. gigantica) infecting several herbivorous mammals including cattle, goats, sheep, and humans. We report a 9-year-old girl who suffered from F. hepatica infection and underwent right hepatectomy because of increasing abdominal ...
متن کاملRelative importance of meteorological and geographical factors in the distribution of Fasciola hepatica infestation in farmed sheep in Qinghai province, China
Fasciola hepatica is an important trematode parasite of economic importance that infests sheep and cattle worldwide. We conducted a detailed investigation into the spatial distribution of F. hepatica infestation in farmed sheep in Qinghai (Wutumeiren) province, Mainland China. Mathematical modelling was used to assess the inter-relationships between meteorological and geographical factors and t...
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